研究業績
原著
2021
Maemura, M., Taketsuru, H., Nakajima, Y., Shao, R., Kakihara, A., Nogami, J., Ohkawa, Y.,
Tsukada, Y.:
Totipotency of mouse zygotes extends to single blastomeres of embryos at the four-cell stage.Sci. Rep., 11: 11167 (2021).
[PubMed] [Press release] 2019
Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J.,
Tsukada, Y., Yamanaka, S., Takamura-Enya, T., Lu, Q., Yoshimura, A.:
Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression. Int. Immunol., 31: 335-347 (2019).
[PubMed] 2017
Someya, K., Nakatsukasa, H., Ito, M., Kondo, T., Tateda, K. I., Akanuma, T., Koya, I., Sanosaka, T., Kohyama, J.,
Tsukada, Y., Takamura-Enya, T., Yoshimura, A.:
Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation.Int. Immunol., 29: 365-375 (2017).
[PubMed] 2015
Hatanaka, Y., Inoue., K, Oikawa, M., Kamimura, S., Ogonuki, N., Kodama, E. N., Ohkawa, Y.,
Tsukada, Y., Ogura, A.:
Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.Proc. Natl. Acad. Sci. USA, 112: 14641-14646 (2015).
[PubMed]Tsukada, Y., Akiyama, T., Nakayama, K. I.:
Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.Sci. Rep., 5: 15876 (2015).
[PubMed] 2013-2001
Suzuki, T., Ozasa, H., Itoh, Y., Zhan, P., Sawada, H., Mino, K., Walport, L., Ohkubo, R., Kawamura, A., Yonezawa, M.,
Tsukada, Y., Tumber, A., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T., Schofield, C., Miyata, N.:
Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity.J. Med. Chem., 56: 7222-7231 (2013).
[PubMed]Tsukada, Y., Ishitani, T., Nakayama, K. I.:
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development.Genes Dev. (selected as cover), 24: 432-437 (2010).
[PubMed]Nishiyama, M., Oshikawa, K.,
Tsukada, Y., Nakagawa, T., Iemura, S., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, I. A., Nakayama, K. I.:
CDH8 suppresses p53-mediated apoptosis during early embryogenesis.Nat. Cell Biol., 11: 172-182 (2009).
[PubMed]He, J., Kallin, E. M.,
Tsukada, Y., Zhang, Y.:
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b.Nat. Struct. Mol. Biol., 15: 1169-1175 (2008).
[PubMed]Shirako, E., Hirayama, N.,
Tsukada, Y., Tanaka, T., Kitamura, N.:
Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation.J. Cell. Biochem., 104: 176-188 (2008).
[PubMed]Yamane, K., Toumazou, C.,
Tsukada, Y., Erdjument-Bromage, H., Tempst, P., Wong, J., Zhang, Y.:
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.Cell, 125: 483-495 (2006).
[PubMed]Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M. E., Borchers, C. H., Tempst, P., Zhang, Y.:
Histone demethylation by a family of JmjC domain-containing proteins.Nature (Article), 439: 811-816 (2006).
[PubMed]Maemura, M., Yoshimoto, A.,
Tsukada, Y., Morishita, Y., Miyazawa, K., Tanaka. T., Kitamura, N.:
Inhibitory effect of c-Met mutants on the formation of branching tubules by a porcine aortic endothelial cell line.
Cancer Sci., 97: 1343-1350 (2006).
[PubMed]Cao, R.,
Tsukada, Y., Zhang, Y.:
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.Mol. Cell, 20: 845-854 (2005).
[PubMed]Han, J.,
Tsukada, Y., Hara, E., Kitamura, N., Tanaka, T.:
Hepatocyte growth factor induces redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.J. Biol. Chem., 280: 31548-31556 (2005).
[PubMed]Tsukada, Y., Tanaka, T., Miyazawa, K., Kitamura, N.:
Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.J. Biochem., 136: 701-709 (2004).
[PubMed]Tsukada, Y., Miyazawa, K., Kitamura, N.:
High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2.J. Biol. Chem., 276: 40968-40976 (2001).
[PubMed]
